Title of article
A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors
Author/Authors
Namal C. Warshakoon، نويسنده , , Shengde Wu، نويسنده , , Angelique Boyer، نويسنده , , Richard Kawamoto، نويسنده , , Justin Sheville، نويسنده , , Sean Renock، نويسنده , , Kevin Xu، نويسنده , , Matthew Pokross، نويسنده , , Artem G. Evdokimov، نويسنده , , Richard Walter، نويسنده , , Marlene Mekel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5598
To page
5601
Abstract
Utilizing modeling information from a recently resolved structure of human HIF-1α prolyl hydroxylase (EGLN1) and structure-based design, a novel series of imidazo[1,2-a]pyridine derivatives was prepared. The activity of these compounds was determined in a human EGLN1 assay and a limited SAR was developed.
Keywords
2-a]pyridines , HIF-1? prolyl hydroxylase inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797436
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