Title of article
A protein kinase signal-responsive gene carrier modified RGD peptide
Author/Authors
Jun Oishi، نويسنده , , Moeko Ijuin، نويسنده , , Tatsuhiko Sonoda، نويسنده , , Jeong-Hun Kang، نويسنده , , By KENJI KAWAMURA، نويسنده , , Takeshi Mori، نويسنده , , Takuro Niidome، نويسنده , , Yoshiki Katayama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5740
To page
5743
Abstract
We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.
Keywords
Gene Therapy , protein kinase , RGD peptide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797464
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