Title of article :
Effects of α-substitutions on structure and biological activity of anticancer chalcones
Author/Authors :
Nicholas J. Lawrence، نويسنده , , Richard P. Patterson، نويسنده , , Li-Ling Ooi، نويسنده , , Darren Cook، نويسنده , , Sylvie Ducki، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different α-substitutions, in particular α-fluorination, on the structure and biological activity of a series of chalcones.
Keywords :
Tubulin , Fluorine , Fluorination , Anticancer , chalcone
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
