Title of article
Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers
Author/Authors
Andrew Fluxe، نويسنده , , Shengde Wu، نويسنده , , James B. Sheffer، نويسنده , , John M. Janusz، نويسنده , , Michael Murawsky، نويسنده , , Gina M. Fadayel، نويسنده , , Bin Fang، نويسنده , , Michelle Hare، نويسنده , , Laurent Djandjighian، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5855
To page
5858
Abstract
A novel class of tetrahydroindolone-derived carbamates has been discovered whose members are potent Kv1.5 blockers. The in vitro data show that compounds 6 and 29 are quite potent. They are also very selective over hERG (>450-fold) and L-type calcium channels (>450-fold).
Keywords
Carbamate , Kv1.5 blocker , Atrial antiarrhythmic , In vitro efficacy
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797489
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