Title of article :
Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt
Author/Authors :
Jong Hee Ko، نويسنده , , Seung Woo Yeon، نويسنده , , Jung Su Ryu، نويسنده , , Tae-Yong Kim، نويسنده , , Eun-Ha Song، نويسنده , , Hea-Jung Kim، نويسنده , , Rae-Eun Park، نويسنده , , Chung-Kyu Ryu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A series of 5-arylamino-6-chloro-1H-indazole-4,7-diones were synthesized and evaluated for their inhibitory activity on protein kinase B/Akt. The compounds exhibited a potent Akt1 inhibitory activity. Further mechanistic study revealed that they might have dual inhibitory effects on both activity and phosphorylation of Akt1 in PC-3 tumor cell line.
Keywords :
1H-indazole-4 , inhibitor , antitumor , Akt , 7-dione
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
