Author/Authors :
Richard F. Clark، نويسنده , , Tianyuan Zhang، نويسنده , , Zhili Xin، نويسنده , , Gang Liu، نويسنده , , Ying Wang، نويسنده , , T. Matthew Hansen، نويسنده , , Xiaojun Wang، نويسنده , , Rongqi Wang، نويسنده , , Xiaolin Zhang، نويسنده , , Ernst U. Frevert، نويسنده , , Heidi S. Camp، نويسنده , , Bruce A. Beutel، نويسنده , , Hing L. Sham، نويسنده , , Yu Gui Gu، نويسنده ,
Abstract :
Structure–activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the lead scaffold resulted in the identification of compounds exhibiting low-nanomolar potency and isozyme-selective ACC2 activity.
Keywords :
type 2 diabetes , obesity , insulin resistance , Acetyl-CoA carboxylase
