Title of article
Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists
Author/Authors
Steven J. Richards، نويسنده , , Thomas W. von Geldern، نويسنده , , Peer Jacobson، نويسنده , , DeniseWilcox، نويسنده , , Phong Nguyen، نويسنده , , Lars ?hman، نويسنده , , Marie ?sterlund، نويسنده , , Birgitta Gelius، نويسنده , , Marlena Grynfarb، نويسنده , , Annika Goos-Nilsson، نويسنده , , Jiahong Wang، نويسنده , , Steven Fung، نويسنده , , Masha Kalmanovich، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
6086
To page
6090
Abstract
A series of potent steroidal glucocorticoid receptor antagonists has been discovered. After conjugation to cholic acid, the compounds retained an affinity for GR in vitro and had modest in vivo efficacy.
Keywords
Glucocorticoid receptor , Bile-acid , Liver-targeting , RU-486 , steroid , Glucocorticoids , cortisol , prednisolone , Antagonist , Cholic acid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797533
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