Title of article
Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
Author/Authors
Romen Carrillo، نويسنده , , Leticia G. Le?n، نويسنده , , Tomas Martin، نويسنده , , Victor S. Martin، نويسنده , , José M. Padr?n، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
6135
To page
6138
Abstract
In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the α,β-unsaturated ester side chain at position 2 of the THP ring.
Keywords
Marine products , Anticancer drugs , Cyclic ethers , Solid tumors , structure–activity relationship
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797543
Link To Document