Title of article
Natural inhibitors targeting osteoclast-mediated bone resorption
Author/Authors
Guang-Zhi Zeng، نويسنده , , Ning-Hua Tan، نويسنده , , Xiaojiang Hao، نويسنده , , Quan-Zhang Mu، نويسنده , , Rong-Tao Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
6178
To page
6180
Abstract
Human cathepsin K, matrix metalloproteinase 9, and αVβ3 integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1–10 for them by enzyme inhibition assays. Inhibitors 1–7, 8–9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and αVβ3, respectively.
Keywords
bone resorption , Cathepsin K , matrix metalloproteinase 9 , ?v?3 , Natural inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797550
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