Title of article
Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers
Author/Authors
Shengde Wu، نويسنده , , Andrew Fluxe، نويسنده , , Jim Sheffer، نويسنده , , John M. Janusz، نويسنده , , Benjamin E. Blass، نويسنده , , Ron White، نويسنده , , Chris Jackson، نويسنده , , Richard Hedges، نويسنده , , Michael Murawsky، نويسنده , , Bin Fang، نويسنده , , Gina M. Fadayel، نويسنده , , Michelle Hare، نويسنده , , Laurent Djandjighian، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
6213
To page
6218
Abstract
A novel class of tetrazole-derived Kv1.5 blockers is disclosed. In in vitro studies, several compounds had IC50s ranging from 180 to 550 nM. In vivo studies indicated that compounds 2f and 2j increased right atrial ERP about 40% without affecting ventricular ERP.
Keywords
Tetrazoles , Atrial antiarrhythmic , Kv1.5 blocker , In vivo efficacy
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797558
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