Title of article
Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome
Author/Authors
Steven Richards، نويسنده , , Bryan Sorensen، نويسنده , , Hwan-Soo Jae، نويسنده , , Marty Winn، نويسنده , , Yixian Chen، نويسنده , , Jiahong Wang، نويسنده , , Steven Fung، نويسنده , , Katina Monzon، نويسنده , , Ernst U. Frevert، نويسنده , , Peer Jacobson، نويسنده , , Hing Sham، نويسنده , , J.T Link، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
6241
To page
6245
Abstract
High throughput screening efforts have identified a novel class of dichloroaniline amide 11β-HSD1 inhibitors. SAR studies initiated from dichloroaniline 4 focused on retaining the potency and selectivity profile of the lead.
Keywords
11?-hydroxysteroid dehydrogenase , 11?-HSD1 inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797563
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