Title of article :
Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A
Author/Authors :
Tadashi Honda، نويسنده , , Karen T. Liby، نويسنده , , Xiaobo Su، نويسنده , , Chitra Sundararajan، نويسنده , , Yukiko Honda، نويسنده , , Nanjoo Suh، نويسنده , , Renee Risingsong، نويسنده , , Charlotte R. Williams، نويسنده , , Darlene B. Royce، نويسنده , , Michael B. Sporn، نويسنده , , Gordon W. Gribble، نويسنده ,
Abstract :
Fifteen new betulinic acid analogues were designed, synthesized, and tested for anti-inflammatory activity. Many of these analogues effectively suppress nitric oxide (NO) production in RAW cells stimulated with interferon-γ. Analogue 10 is highly and orally active in vivo for induction of the anti-inflammatory and cytoprotective enzyme, heme oxygenase-1.
Keywords :
betulinic acid , Inhibitors of nitric oxide production , RAW 264.7 cells , Inducer of heme oxygenase-1 , Triterpene
