Title of article
Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure
Author/Authors
Shunqi Yan، نويسنده , , Gary Larson، نويسنده , , Jim Z. Wu، نويسنده , , Todd Appleby، نويسنده , , Yili Ding، نويسنده , , Robert Hamatake، نويسنده , , Zhi Hong، نويسنده , , Nanhua Yao، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
63
To page
67
Abstract
Structure–activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2 Å, and confirmed the design.
Keywords
NS5B inhibitor , HCV , HCV NS5B polymerase , tetrazole , Thiazolone , NS5B , HCV NS5B inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797597
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