Title of article :
Estrogen receptor β ligands: Design and synthesis of new 2-phenyl-isoindole-1,3-diones
Author/Authors :
John W. Ullrich، نويسنده , , Rayomand J. Unwalla and William S. Somers، نويسنده , , Robert R. Singhaus Jr.، نويسنده , , Heather A. Harris، نويسنده , , Richard E. Mewshaw، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.
Keywords :
ER? and ER? receptor , nuclear hormone receptor , estrogen receptor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
