Title of article
4-Aminopyrimidines as novel HIV-1 inhibitors
Author/Authors
Venkat R. Gadhachanda، نويسنده , , Baogen Wu، نويسنده , , Zhiwei Wang، نويسنده , , Kelli L. Kuhen، نويسنده , , Jeremy Caldwell، نويسنده , , Helmut Zondler، نويسنده , , Harald Walter، نويسنده , , Mark Havenhand، نويسنده , , Yun He، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
260
To page
265
Abstract
A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.
Keywords
Aminopyrimidine , HIV-1 inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797638
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