• Title of article

    Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP

  • Author/Authors

    Richard J. Davenport، نويسنده , , Paloma Diaz، نويسنده , , Frances C.A. Galvin، نويسنده , , Steve Lloyd، نويسنده , , Stephen R. Mack، نويسنده , , Ray Owens، نويسنده , , Verity Sabin، نويسنده , , Joanne Wynn، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2007
  • Pages
    4
  • From page
    558
  • To page
    561
  • Abstract
    The synthesis of a series of novel C-linked nucleotide triphosphates is reported. These exhibit excellent agonist potency and selectivity for the P2Y2 receptor with a number of examples having EC50 values below 10 nM. Representative compounds from the N-linked and C-linked series showed enhanced metabolic stability compared with that of the natural ligand UTP.
  • Keywords
    P2Y2 , UTP , Enhanced stability
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2007
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797696

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797696