Author/Authors :
Richard J. Davenport، نويسنده , , Paloma Diaz، نويسنده , , Frances C.A. Galvin، نويسنده , , Steve Lloyd، نويسنده , , Stephen R. Mack، نويسنده , , Ray Owens، نويسنده , , Verity Sabin، نويسنده , , Joanne Wynn، نويسنده ,
Abstract :
The synthesis of a series of novel C-linked nucleotide triphosphates is reported. These exhibit excellent agonist potency and selectivity for the P2Y2 receptor with a number of examples having EC50 values below 10 nM. Representative compounds from the N-linked and C-linked series showed enhanced metabolic stability compared with that of the natural ligand UTP.
