Author/Authors :
Mei Liu، نويسنده , , Sanyi Wang، نويسنده , , Jill E. Clampit، نويسنده , , Rebecca J. Gum، نويسنده , , Deanna L. Haasch، نويسنده , , Cristina M. Rondinone، نويسنده , , James M. Trevillyan، نويسنده , , Cele Abad-Zapatero، نويسنده , , Elizabeth H. Fry، نويسنده , , Hing L. Sham، نويسنده , , Gang Liu، نويسنده ,
Abstract :
A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described.
Keywords :
JNK inhibitors , Diabetes , obesity , kinase
