Title of article
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies
Author/Authors
Mei Liu، نويسنده , , Sanyi Wang، نويسنده , , Jill E. Clampit، نويسنده , , Rebecca J. Gum، نويسنده , , Deanna L. Haasch، نويسنده , , Cristina M. Rondinone، نويسنده , , James M. Trevillyan، نويسنده , , Cele Abad-Zapatero، نويسنده , , Elizabeth H. Fry، نويسنده , , Hing L. Sham، نويسنده , , Gang Liu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
668
To page
672
Abstract
A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described.
Keywords
JNK inhibitors , Diabetes , obesity , kinase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797716
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