Title of article :
Design, synthesis, and evaluation of efflux substrate–metal chelator conjugates as potential antimicrobial agents
Author/Authors :
Yanling Zhang، نويسنده , , C. Eric Ballard، نويسنده , , Shi Long Zheng، نويسنده , , Xingming Gao، نويسنده , , Ko-Chun Ko، نويسنده , , Hsiuchin Yang، نويسنده , , Gary Brandt، نويسنده , , Xinhui Lou، نويسنده , , Phang C. Tai، نويسنده , , Chung-Dar Lu، نويسنده , , Binghe Wang، نويسنده ,
Abstract :
Maintaining a proper balance of metal concentrations is critical to the survival of bacteria. We have designed and synthesized a series of conjugates of metal chelators and efflux transporter substrates aimed at disrupting bacterial metal homeostasis to achieve bacterial killing. Biological studies showed that two of the compounds had very significant antimicrobial effect with an MIC value of 7.8 μg/mL against Gram-positive Bacillus subtilis.
Keywords :
Design , synthesis , Antimicrobial agents , Efflux substrate–metal chelator conjugates
