Title of article
Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers
Author/Authors
Ahmed Kamal، نويسنده , , D. Rajasekhar Reddy، نويسنده , , P.S. Murali Mohan Reddy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
803
To page
806
Abstract
C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (ΔTm) of 18.8 °C after incubation of 36 h at 37 °C.
Keywords
DNA-binding ability , Pyrrolobenzodiazepine , DC-81
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797744
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