Title of article
Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists
Author/Authors
Hee Oon Han، نويسنده , , Seung Hae Kim، نويسنده , , Kyoung-Hee Kim، نويسنده , , Gwong-Cheung Hur، نويسنده , , Hyeon Joo Yim، نويسنده , , Hee-Kyung Chung، نويسنده , , Sung Ho Woo، نويسنده , , Ki Dong Koo، نويسنده , , Chang-Seok Lee، نويسنده , , Jong Sung Koh، نويسنده , , Geun Tae Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
937
To page
941
Abstract
Oxime ethers of α-acyl-β-phenylpropanoic acids were prepared to apply as PPARα and γ dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC50 of 19 and 13 nM in PPARα and γ, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model.
Keywords
dual agonist , Propanoic acid , PPAR , oxime
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797767
Link To Document