Title of article
Inhibitors of the FEZ-1 metallo-β-lactamase
Author/Authors
Benoît M.R. Liénard، نويسنده , , Louise E. Horsfall، نويسنده , , Moreno Galleni، نويسنده , , Jean-Marie Frère and Jozef Van Beeumen، نويسنده , , Andrea G. Prescott and Christopher J. Schofield، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
964
To page
968
Abstract
Metallo-β-lactamases (MBLs) catalyze the hydrolysis of β-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a Ki of 6.1 ± 0.7 μM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.
Keywords
antibiotic , structure–activity relationship , inhibition , Metallo-?-lactamases
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797773
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