Title of article
13C bis-labeled pyrroles: A tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester
Author/Authors
Fabrizio Micheli، نويسنده , , Paolo Cavanni، نويسنده , , Romano Di Fabio، نويسنده , , Daniele Donati، نويسنده , , Mahmoud Hamdan، نويسنده , , Stefano Provera، نويسنده , , Maria Elvira Tranquillini، نويسنده , , Giovanni Vitulli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
969
To page
973
Abstract
Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester as a potent and selective mGluR1 non-competitive antagonist, the use of a doubly 13C-labeled analogue to identify, and consequently prevent, metabolically labile positions is reported.
Keywords
metabolism , Metabotropic , glutamate , mGluR1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797774
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