Title of article
Design and synthesis of a novel class of dual PPARγ/δ agonists
Author/Authors
Isabel C. Gonzalez، نويسنده , , Jason Lamar، نويسنده , , Fatima Iradier، نويسنده , , Yanping Xu، نويسنده , , Leonard L. Winneroski، نويسنده , , Jeremy York، نويسنده , , Nathan Yumibe، نويسنده , , Richard Zink، نويسنده , , Chahrzad Montrose-Rafizadeh، نويسنده , , Gary J. Etgen، نويسنده , , Carol L. Broderick، نويسنده , , Brian A. Oldham، نويسنده , , Nathan Mantlo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
1052
To page
1055
Abstract
The design and synthesis of dual PPAR γ/δ agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relative to rosiglitazone at an equivalent level of glucose control.
Keywords
Diabetes , dyslipidemia , PPAR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797791
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