Title of article
Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety
Author/Authors
Lei Fang، نويسنده , , Yihua Zhang، نويسنده , , Jochen Lehmann، نويسنده , , You Wang، نويسنده , , Hui Ji، نويسنده , , Dayong Ding، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1062
To page
1066
Abstract
A series of furoxan-based nitric oxide-releasing glucocorticoid derivatives was synthesized. The pharmacological assays indicated that three compounds, including I4, I5, and I6, had anti-inflammatory activity. Furthermore compared with the leading compound hydrocortisone the safety of I6 was greatly improved. Due to releasing NO in vivo the side effects of glucocorticoids, including hypertension and osteoporosis, were effectively avoided.
Keywords
Glucocorticoids , hydrocortisone , Furoxan , NO-donors , Anti-inflammatory activity , safety
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797793
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