Title of article :
Synthesis of a novel inhibitor against MRSA and VRE: Preparation from zerumbone ring opening material showing histidine-kinase inhibition
Author/Authors :
Takashi Kitayama، نويسنده , , Risa Iwabuchi، نويسنده , , Shu Minagawa، نويسنده , , Seiji Sawada، نويسنده , , Ryo Okumura، نويسنده , , Kazuki Hoshino، نويسنده , , John Cappiello، نويسنده , , Ryutaro Utsumi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Zerumbone ring-opening derivative 2 inhibited autophosphorylation of the essential histidine protein kinase (HPK), YycG, existing in Bacillus subtilis constituting a two-component system (TCS). However, it did not inhibit drug-resistant bacterium such as MRSA and VRE. Tryptophan derivative 34 also could be regulated by a TCS system like 2. In addition, 34 showed good inhibition against MRSA and VRE.
Keywords :
YycG , MRSA , Drug-resistant bacterium , Zerumbone , VRE , inhibitor , Two-component system , Histidine kinase
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
