Title of article
Discovery of thienopyridines as Src-family selective Lck inhibitors
Author/Authors
Lily Abbott، نويسنده , , Patrick Betschmann، نويسنده , , Andrew Burchat، نويسنده , , David J. Calderwood، نويسنده , , Heather Davis، نويسنده , , Peter Hrnciar، نويسنده , , Gavin C. Hirst، نويسنده , , Biqin Li، نويسنده , , Michael Morytko، نويسنده , , Kelly Mullen، نويسنده , , Bryant Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1167
To page
1171
Abstract
We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed based on a desire to access the unique residues in the extended hinge region of Lck.
Keywords
Lck inhibitors , Src-family , Kinase inhibitors , Thienopyridines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797810
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