Title of article
Quinazoline and benzimidazole MCH-1R antagonists
Author/Authors
Rosa Arienzo، نويسنده , , Sue Cramp، نويسنده , , Hazel J. Dyke، نويسنده , , Peter M. Lockey، نويسنده , , Dennis Norman، نويسنده , , Alan G. Roach، نويسنده , , Phil Smith، نويسنده , , Melanie Wong، نويسنده , , Stephen P. Wren، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1403
To page
1407
Abstract
We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro eADME profiles.
Keywords
OBESITY , Melanin-concentrating hormone , MCH-1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797858
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