Title of article
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Author/Authors
James E. Sheppeck II، نويسنده , , John L. Gilmore، نويسنده , , Anle Yang، نويسنده , , Xiao-Tao Chen، نويسنده , , Chu-Biao Xue، نويسنده , , John Roderick، نويسنده , , Ruiqin Liu، نويسنده , , Maryanne B. Covington، نويسنده , , Carl P. Decicco، نويسنده , , James J. -W. Duan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1413
To page
1417
Abstract
A series of novel hydantoins was designed and synthesized as structural alternatives to hydroxamate inhibitors of TACE. 5-Mono- and di-substituted hydantoins exhibited activity with IC50 values of 11–60 nM against porcine TACE in vitro and excellent selectivity against other MMPs.
Keywords
TACE , Non-hydroxamate , TACE inhibitor , MMP , matrix metalloprotease , matrix metalloproteinase , TNF
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797860
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