Title of article
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening
Author/Authors
Georgina A. Holloway، نويسنده , , Jonathan B. Baell، نويسنده , , Alan H. Fairlamb، نويسنده , , Patrizia M. Novello، نويسنده , , John P. Parisot، نويسنده , , John Richardson، نويسنده , , Keith G. Watson، نويسنده , , Ian P. Street، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
1422
To page
1427
Abstract
A high-throughput screening campaign of a library of 100,000 lead-like compounds identified 2-iminobenzimidazoles as a novel class of trypanothione reductase inhibitors. These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely related human glutathione reductase and have low cytotoxicity against mammalian cells.
Keywords
Tropical diseases , Trypanosomiasis therapeutics , Trypanothione reductase inhibitors , High-throughput screening , medicinal chemistry , Iminobenzimidazoles
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797862
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