Title of article
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation
Author/Authors
Seong Rim Byeon، نويسنده , , Ji-Hoon Lee، نويسنده , , Ji-Hoon Sohn، نويسنده , , Dong Chan Kim، نويسنده , , Kye Jung Shin، نويسنده , , Kyung Ho Yoo، نويسنده , , Inhee Mook-Jung، نويسنده , , Won Koo Lee، نويسنده , , Dong Jin Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1466
To page
1470
Abstract
New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by Aβ fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activities for Aβ fibril formation at IC50 of 0.1–2.7 μM which is comparable to curcumin (IC50 of 0.8 μM). Among them, nine compounds were screened for their cytotoxicities on HT-22 cell by MTT assay at 1, 10, and 50 μM. In particular, I-7 and II-2 exhibited the best combination of inhibitory activity and compound cytotoxicity.
Keywords
A? fibril formation inhibitor , Alzheimer disease , Bis-styrylpyridine , Bis-styrylbenzene , Amyloid ?
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797870
Link To Document