Title of article
Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors
Author/Authors
Fedra M. Leonik، نويسنده , , Roger L. Papke، نويسنده , , Nicole A. Horenstein، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
3
From page
1520
To page
1522
Abstract
The α7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists deriving from the quinuclidine scaffold. Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC50s of 1.5 and 40 μM, respectively.
Keywords
Quinuclidine , olefination , agonist , nAChR , Acetylcholine , Nicotinic , receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797878
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