Title of article
Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones
Author/Authors
Arjan van Oeveren، نويسنده , , Barbara A. Pio، نويسنده , , Christopher M. Tegley، نويسنده , , Robert I. Higuchi، نويسنده , , Min Wu، نويسنده , , Todd K. Jones، نويسنده , , Keith B. Marschke، نويسنده , , Andrés Negro-Vilar، نويسنده , , Lin Zhi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
1523
To page
1526
Abstract
A series of alkylamino-2-quinolinone compounds (3) was discovered as androgen receptor modulators based on an early linear tricyclic quinoline pharmacophore (1). The series demonstrated selective high binding affinity to androgen receptor and potent receptor modulating activities in the cotransfection assays.
Keywords
androgen receptor , SARM , 2-Quinolinone , AR antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797879
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