Title of article
Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid
Author/Authors
Zyta Ziora، نويسنده , , Soko Kasai، نويسنده , , Koushi Hidaka، نويسنده , , Ayaka Nagamine، نويسنده , , Tooru Kimura، نويسنده , , Yoshio Hayashi، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
1629
To page
1633
Abstract
A novel norstatine derivative, phenylthionorstatine [(2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid; Ptns], containing a hydroxymethylcarbonyl (HMC) isostere was designed, synthesized, and stereochemically determined. Then, Ptns was introduced into the structure of BACE1 inhibitors at the P1 position. Finally, Ptns was found as a suitable P1 moiety for potent BACE1 inhibitor design.
Keywords
BACE1 inhibitor , Norstatine , Hydroxymethylcarbonyl isostere , Alzheimer’s Disease
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797901
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