Title of article
Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists
Author/Authors
Tao Guo، نويسنده , , Huizhong Gu، نويسنده , , Doug W. Hobbs، نويسنده , , Dennis E. Busler، نويسنده , , Laura L. Rokosz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
1718
To page
1721
Abstract
Melanin concentrating hormone (MCH) plays an important role in the regulation of food intake and energy balance in mammals. MCH-1 receptor (MCH1R) deficient mice are lean and resistant to diet-induced obesity. As such, MCH1R antagonists are believed to have potential as possible treatments for obesity. The discovery of a novel class of tetralin ureas as potent MCH1R antagonists is described herein.
Keywords
MCH1R antagonists , obesity , MCH
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797920
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