Title of article
Butyl 2-(4-[1.1′-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain
Author/Authors
Anne-Marie Liberatore، نويسنده , , Jocelyne Schulz، نويسنده , , Christine Favre-Guilmard، نويسنده , , Jacques Pommier، نويسنده , , Jacques Lannoy، نويسنده , , Emilia Pawlowski، نويسنده , , Marie-Anne Barthelemy، نويسنده , , Marion Huchet، نويسنده , , Michel Auguet، نويسنده , , Pierre-Etienne Chabrier، نويسنده , , Dennis Bigg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
1746
To page
1749
Abstract
A series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain models in vivo.
Keywords
Neuropathic pain , Sodium channel modulators , Treatment
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797926
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