Title of article :
HeLa cells apoptosis induced by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane
Author/Authors :
Li Yang، نويسنده , , Feng Liang، نويسنده , , Min Liu، نويسنده , , Congyi Zheng، نويسنده , , Shuhui Wan، نويسنده , , Xiaoqin Xiong، نويسنده , , Xiaolian Zhang، نويسنده , , Zhi-Chao Shen ، نويسنده , , Xiang Zhou، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Preliminary pharmacological tests showed that 1,7-dimethyl-1,4,7,10-tetraazacyclododecane (DMC) had antitumor activity against HeLa and A549 cell lines in vitro. The HeLa cells apoptosis induced by DMC was examined by flow cytometric meter, and further confirmed by observing the morphological changes and DNA fragmentation. No observation of A549 cells induced apoptosis was observed by DMC.
Keywords :
apoptosis , Antitumor activity , Macrocyclic polyamines
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
