Title of article :
Production of aminoglycosides in non-aminoglycoside producing Streptomyces lividans TK24
Author/Authors :
Bimala Subba، نويسنده , , Nagendra Prasad Kurumbang، نويسنده , , Young Soo Jung، نويسنده , , Yeo Joon Yoon، نويسنده , , Hei Chan Lee، نويسنده , , Kwangkyoung Liou، نويسنده , , Jae Kyung Sohng، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
The pRBM4 cosmid, which harbors a putative cluster of genes spanning a 31.8-kb chromosomal region of the ribostamycin producer Streptomyces ribosidificus ATCC 21294, was heterologously expressed in Streptomyces lividans TK24. ESI-MS/MS, HPLC, and LC-ESI MS analyses showed that the transformation gave rise to ribostamycin production in various culture broths. This is the first report of heterologous aminoglycoside production.
Keywords :
aminoglycoside , Heterologous expression , Ribostamycin , Streptomyces lividans TK 24
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
