Author/Authors :
Yeon Sun Lee، نويسنده , , Joel Nyberg، نويسنده , , Sharif Moye، نويسنده , , Richard S. Agnes، نويسنده , , Peg Davis، نويسنده , , Shou-Wu Ma، نويسنده , , Joséphine Lai Kee Him، نويسنده , , Frank Porreca، نويسنده , , Ruben Vardanyan، نويسنده , , Victor J. Hruby، نويسنده ,
Abstract :
New 4-anilidopiperidine analogues in which the phenethyl group of fentanyl was replaced by several aromatic ring-contained amino acids (or acids) were synthesized to study the biological effect of the substituents on μ and δ opioid receptor interactions. These analogues showed broad (47 nM–76 μM) but selective (up to 17-fold) binding affinities at the μ opioid receptor over the δ opioid receptor, as predicted from the message-address concept.
Keywords :
Analgesic effects , Dmt-Tic , Fentanyl , 4-Anilidopiperidine analogues , Opioid receptors
