Title of article
Design and synthesis of novel prodrugs of 2′-deoxy-2′-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues
Author/Authors
Yasunori Kohchi، نويسنده , , Kazuo Hattori، نويسنده , , Nobuhiro Oikawa، نويسنده , , Eisaku Mizuguchi، نويسنده , , Yoshiaki Isshiki، نويسنده , , Kohsuke Aso، نويسنده , , Kiyoshi Yoshinari، نويسنده , , Haruyoshi Shirai، نويسنده , , Masanori Miwa، نويسنده , , Yukiko Inagaki، نويسنده , , Masako Ura، نويسنده , , Kotaroh Ogawa، نويسنده , , Hisafumi Okabe، نويسنده , , Hideo Ishitsuka، نويسنده , , Nobuo Shimma، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2241
To page
2245
Abstract
DNA microarray analysis comparing human tumor tissues with normal tissues including hematopoietic progenitor cells resulted in identification of membrane dipeptidase as a prodrug activation enzyme. Novel prodrugs of 2′-deoxy-2′-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety.
Keywords
Tumor targeting , prodrug , antitumor , Cytotoxic agent
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798018
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