Title of article :
Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives
Author/Authors :
A. Chris Krueger، نويسنده , , Darold L. Madigan، نويسنده , , Brian E. Green، نويسنده , , Douglas K. Hutchinson، نويسنده , , Wen W. Jiang، نويسنده , , Warren M. Kati، نويسنده , , Yaya Liu، نويسنده , , Clarence J. Maring، نويسنده , , Sherie V. Masse، نويسنده , , Keith F. McDaniel، نويسنده , , Tim R. Middleton، نويسنده , , Hongmei Mo، نويسنده , , Akhteruzzaman Molla، نويسنده , , Debra A. Montgomery، نويسنده , , Teresa I. Ng، نويسنده , , Dale J. Kempf، نويسنده ,
Abstract :
Substituted 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives were investigated as inhibitors of genotype 1 HCV polymerase. Structure–activity relationship patterns for this class of compounds are discussed. It was found that the saturated alkane dialkyl units provided the most active analogs.
Keywords :
HCV , NS5B , polymerase , 4-dialkyl-3-oxo-3 , 4-dihydronaphthalene benzothiadiazine , 1-Hydroxy-4
