Title of article
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties
Author/Authors
Matthew W. Martin، نويسنده , , John Newcomb، نويسنده , , Joseph J. Nunes، نويسنده , , Jean E. Bemis، نويسنده , , David C. McGowan، نويسنده , , Ryan D. White، نويسنده , , John L. Buchanan، نويسنده , , Erin F. DiMauro، نويسنده , , Christina Boucher، نويسنده , , Theodore Faust، نويسنده , , Faye Hsieh، نويسنده , , Xin Huang، نويسنده , , Josie H. Lee، نويسنده , , Stephen Schneider، نويسنده , , Susan M. Turci، نويسنده , , Xiaotian Zhu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
2299
To page
2304
Abstract
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties.
Keywords
Lck inhibitor , kinase inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798030
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