Title of article :
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties
Author/Authors :
Matthew W. Martin، نويسنده , , John Newcomb، نويسنده , , Joseph J. Nunes، نويسنده , , Jean E. Bemis، نويسنده , , David C. McGowan، نويسنده , , Ryan D. White، نويسنده , , John L. Buchanan، نويسنده , , Erin F. DiMauro، نويسنده , , Christina Boucher، نويسنده , , Theodore Faust، نويسنده , , Faye Hsieh، نويسنده , , Xin Huang، نويسنده , , Josie H. Lee، نويسنده , , Stephen Schneider، نويسنده , , Susan M. Turci، نويسنده , , Xiaotian Zhu، نويسنده ,
Abstract :
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties.
