Title of article
Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics
Author/Authors
Luca Gentilucci*، نويسنده , , Giuliana Cardillo، نويسنده , , Federico Squassabia، نويسنده , , Alessandra Tolomelli، نويسنده , , Santi Spampinato، نويسنده , , Antonino Sparta، نويسنده , , Monica Baiula، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2329
To page
2333
Abstract
In this paper, we describe the synthesis of a selected library of heterochiral d-Pro-containing RGD-peptidomimetics (RpD) and we investigate the biological activity as inhibitors of fibronectin adhesion to SK-MEL-24 tumor cells. In particular, peptides 4 and 8 showed an IC50 in the 10−8 M range. Despite the linear structure, the peptides tend to adopt a folded conformation in a polar environment.
Keywords
Peptidomimetic , ?-Turn , Conformations , d-Proline , Integrins
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798036
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