Author/Authors :
P?ivi H. Kiviranta، نويسنده , , Jukka Lepp?nen، نويسنده , , Valtteri M. Rinne، نويسنده , , Tiina Suuronen، نويسنده , , Olga Kyrylenko، نويسنده , , Sergiy Kyrylenko، نويسنده , , Erkki Kuusisto، نويسنده , , Anu J. Tervo، نويسنده , , Tomi J?rvinen، نويسنده , , Antero Salminen، نويسنده , , Antti Poso، نويسنده , , Erik A.A. Wallén، نويسنده ,
Abstract :
A series of N-(3-(4-hydroxyphenyl)-propenoyl)-amino acid tryptamides was based on a previously reported new SIRT2 inhibitor from our group, and it was designed to study if the molecular size of the compound could be reduced. The most potent compounds, N-(3-(4-hydroxyphenyl)-propenoyl)-2-aminoisobutyric acid tryptamide and N-(3-(4-hydroxyphenyl)-propenoyl)-l-alanine tryptamide, were equipotent, 30% smaller in molecular weight, and slightly more selective (SIRT2/SIRT1) than the parent compound.
