Title of article
Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors
Author/Authors
Michael A. Letavic، نويسنده , , John M. Keith، نويسنده , , Kiev S. Ly، نويسنده , , Ann J. Barbier، نويسنده , , Jamin D. Boggs، نويسنده , , Sandy J. Wilson، نويسنده , , Brian Lord، نويسنده , , Timothy W. Lovenberg، نويسنده , , Nicholas I. Carruthers، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
2566
To page
2569
Abstract
A series of novel tetrahydronaphthyridine-based histamine H3 ligands that have serotonin reuptake transporter inhibitor activity is described. The 1,2,3,4-tetrahydro-2,6-naphthyridine scaffold is assembled via the addition of a nitrostyrene to a metalated pyridine followed by reduction and cyclization to form the naphthyridine. In vitro biological data for these novel compounds are discussed.
Keywords
Histamine H3 antagonists , Serotonin reuptake inhibitors , naphthyridines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798083
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