Author/Authors :
C. Todd Eary، نويسنده , , Zachary S. Jones، نويسنده , , Robert D. Groneberg، نويسنده , , Laurence E. Burgess، نويسنده , , David A. Mareska، نويسنده , , Mark D. Drew، نويسنده , , James F. Blake، نويسنده , , Ellen R. Laird، نويسنده , , Devan Balachari، نويسنده , , Michael O’Sullivan، نويسنده , , Andrew Allen، نويسنده , , Vivienne Marsh، نويسنده ,
Abstract :
Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterol ester between lipoprotein particles. Inhibition of this protein, in vitro and in vivo, produces an increase in plasma high density lipoprotein cholesterol (HDL-C). This communication will describe the SAR and synthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors from early μ lead to advanced enantiomerically pure analogs.
Keywords :
Tetrahydoquinoxalines , cholesterol , HDL , CETP , cholesteryl ester transfer protein
