Author/Authors :
Om P. Edupuganti، نويسنده , , Valentin Antoci Jr.، نويسنده , , Samuel B. King، نويسنده , , Binoy Jose، نويسنده , , Christopher S. Adams، نويسنده , , Javad Parvizi، نويسنده , , Irving M. Shapiro، نويسنده , , Allen R. Zeiger، نويسنده , , Noreen J. Hickok، نويسنده , , Eric Wickstrom، نويسنده ,
Abstract :
Self-protecting Ti6Al4V alloy pins were prepared by covalent bonding of bis(ethylene glycol) linkers, then vancomycin to the oxidized, aminopropylated Ti6Al4V alloy surface. Fluorescence modification-enabled estimation of yields of free amines on the metallic surface monolayer at each reaction step. The vancomycin-protected Ti6Al4V pins were not colonized by Staphylococcus aureus, even after 44 days storage in physiological buffer. These results provide a basis for testing self-protection against S. aureus colonization in animal models.
Keywords :
antibiotics , biofilms , implants , orthopedics , solid phase synthesis
