Author/Authors :
Tetsuya Toba، نويسنده , , Kenji Murata، نويسنده , , Kyoko Nakanishi، نويسنده , , Bitoku Takahashi، نويسنده , , Naohiro Takemoto، نويسنده , , Minako Akabane، نويسنده , , Takashi Nakatsuka، نويسنده , , Seiichi Imajo، نويسنده , , Takashi Yamamura، نويسنده , , Sachiko Miyake، نويسنده , , Hirokazu Annoura، نويسنده ,
Abstract :
Analogs of immunomodulatory glycolipid OCH (2) were prepared and minimum structure requirement to exhibit equivalent profiles was disclosed. Analogs bearing non-linear hydrocarbon chain in the phytosphingosine moiety (18, 19) were shown for the first time to possess comparable cytokine inducing profile to 2. Molecular modeling of 2/hCD1d complex based on the crystal structure of α-GalCer (1)/hCD1d complex is also described.
