Title of article :
Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors
Author/Authors :
Scott P. Webster، نويسنده , , Peter Ward-Booth، نويسنده , , Margaret Binnie، نويسنده , , Eilidh Craigie، نويسنده , , Kirsty M.M. McConnell، نويسنده , , Karen Sooy، نويسنده , , Andy Vinter، نويسنده , , Jonathan R. Seckl، نويسنده , , Brian R. Walker، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A series of adamantyl amide 11β-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11β-HSD1 over 11β-HSD2 and possess excellent cellular potency in human and murine 11β-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.
Keywords :
HSD1 , 11?-HSD1 , 11?-HSD2 , inhibitor , Adamantane , Amide , Diabetes , enzyme inhibition , 11?-hydroxysteroid dehydrogenase , Metabolic syndrome
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
