Title of article
Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors
Author/Authors
Scott P. Webster، نويسنده , , Peter Ward-Booth، نويسنده , , Margaret Binnie، نويسنده , , Eilidh Craigie، نويسنده , , Kirsty M.M. McConnell، نويسنده , , Karen Sooy، نويسنده , , Andy Vinter، نويسنده , , Jonathan R. Seckl، نويسنده , , Brian R. Walker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
2838
To page
2843
Abstract
A series of adamantyl amide 11β-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11β-HSD1 over 11β-HSD2 and possess excellent cellular potency in human and murine 11β-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.
Keywords
HSD1 , 11?-HSD1 , 11?-HSD2 , inhibitor , Adamantane , Amide , Diabetes , enzyme inhibition , 11?-hydroxysteroid dehydrogenase , Metabolic syndrome
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798134
Link To Document