Title of article
Syntheses and antiproliferative evaluation of oxyphenisatin derivatives
Author/Authors
Muhammed K. Uddin، نويسنده , , Serge G. Reignier، نويسنده , , Tom Coulter، نويسنده , , Christian Montalbetti، نويسنده , , Charlotta Gr?n?s، نويسنده , , Steven Butcher، نويسنده , , Christian Krog-Jensen، نويسنده , , Jakob Felding، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
2854
To page
2857
Abstract
Syntheses and structure–antiproliferative relationship for oxyphenisatin analogues are described. The cell proliferation data showed that the presence of substituents (especially F, Cl, Me, CF3, and OMe) in the 6- and 7-position of oxyphenisatin markedly enhanced the potency in the MDA-468 cell line without affecting the MDA-231 cell line. The best compounds from this series showed low nanomolar antiproliferative activity towards the MDA-468 cell line and a 1000-fold selectivity over the MDA-231 cell line.
Keywords
Phenisatin , MDA-468 cell line , anticancer , antiproliferative , Whole cell assay
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798137
Link To Document