Title of article :
Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists
Author/Authors :
Santosh S. Kulkarni، نويسنده , , Amy Hauck Newman، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5.
Keywords :
Metabotropic glutamate receptor 5 , non-competitive antagonist , Suzuki–Miyaura coupling
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
