Title of article
Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists
Author/Authors
Santosh S. Kulkarni، نويسنده , , Amy Hauck Newman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2987
To page
2991
Abstract
Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5.
Keywords
Metabotropic glutamate receptor 5 , non-competitive antagonist , Suzuki–Miyaura coupling
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798162
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